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- Title
Short-term dipeptidyl peptidase-4 inhibitor use increases the risk of herpes zoster infection in Asian patients with diabetes.
- Authors
Chen, H. -H.; Lin, C. -L.; Yeh, S. -Y.; Kao, C. -H.
- Abstract
Background: We aimed to evaluate whether patients with diabetes who use dipeptidyl peptidase (DPP)-4 inhibitors are at a higher risk of developing a herpes zoster (HZ) infection. Methods: We used a subset of the Longitudinal Health Insurance Database 2000 containing all inpatient and outpatient medical claims of ~1 million people who were randomly sampled from the National Health Insurance Research Database. Patients who were newly diagnosed with Type 2 diabetes International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM 250.x0 and 250.x2) who used antidiabetic medications were divided into two cohorts based on their use of DPP-4 inhibitors between 2009 and 2011. Cox proportion hazard regression models were used to assess the effects of DPP-4 inhibitors on the incidence of HZ compared with the non-DPP-4-inhibitor-exposed cohort. Results: Patients in DPP-4-inhibitor-exposed cohort with diabetes and HZ infections revealed an incidence density of 4.20 per 1000 person-years compared with 3.50 per 1000 person-years for the non-DPP-4-inhibitor-exposed cohort (adjusted hazard ratio [HR]=1.19, 95% confidence interval [CI]=0.70-1.99). Furthermore, high-dose DPP-4-inhibitor treatment was associated with a significantly higher risk of HZ (adjusted HR=2.46, 95% CI=1.16-5.19 for a defined daily dose [DDD]≥360). In addition, short-term DPP-4-inhibitor treatment was associated with a significantly higher risk of HZ (adjusted HR=2.04, 95% CI=1.03-4.04 for a DDD≥360 days). Conclusion: These results suggest that Asian patients with diabetes who use short-termDPP-4 inhibitors might be at a higher risk of developing HZ.
- Subjects
CD26 antigen; ASIANS; HERPES zoster; PEOPLE with diabetes; INSURANCE databases; OUTPATIENT medical care; INFECTIOUS disease transmission; DISEASE risk factors; THERAPEUTICS; DISEASES
- Publication
QJM: An International Journal of Medicine, 2016, Vol 109, Issue 2, p91
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcv096