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- Title
Association between serum selenium level and type 2 diabetes mellitus: a non-linear dose-response meta-analysis of observational studies.
- Authors
Xin-liang Wang; Tu-bao Yang; Jie Wei; Guang-hua Lei; Chao Zeng; Wang, Xin-Liang; Yang, Tu-Bao; Wei, Jie; Lei, Guang-Hua; Zeng, Chao
- Abstract
<bold>Background: </bold>The association between serum selenium levels and type 2 diabetes mellitus (T2DM) is controversial. We performed a systematic review and non-linear dose-response meta-analysis of observational studies to investigate the association in the present study.<bold>Methods: </bold>A comprehensive literature search was conducted using MEDLINE and EMBASE databases. A pooled odds ratio (OR) and related 95 % confidence interval (95 % CI) for T2DM between the highest and lowest serum selenium categories, and a non-linear dose-response relationship between selenium and T2DM were estimated.<bold>Results: </bold>A total of five studies (of 13,460 participants) were identified as meeting the inclusion criteria. The pooled OR indicated that there was a significantly higher prevalence of T2DM in the highest category of blood selenium compared with the lowest (OR = 1.63, 95 % CI: 1.04-2.56, P = 0.033). Moreover, a significant non-linear dose-response relationship was observed between serum selenium levels and T2DM (P < 0.001). Serum selenium levels were positively associated with T2DM in populations with relatively low serum selenium levels (<97.5 μg/l) and those with high serum selenium levels (>132.5 μg/l).<bold>Conclusions: </bold>The positive association between serum selenium levels and T2DM existed in populations with relatively low levels and high levels of serum selenium, indicating a likely U-shaped non-linear dose-response relationship between serum selenium and T2DM.
- Subjects
SELENIUM; TYPE 2 diabetes treatment; META-analysis; MEDLINE; CONFIDENCE intervals; GLUTATHIONE peroxidase
- Publication
Nutrition Journal, 2016, p1
- ISSN
1475-2891
- Publication type
journal article
- DOI
10.1186/s12937-016-0169-6