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- Title
Clonal architecture and single‐cell transcriptome landscape in Richter's syndrome.
- Authors
Li, Heng; Yuan, Lingli; Wang, Peilong; Sheng, Yue; Fu, Zheng; Peng, Hongling
- Abstract
As shown in Figure 2F, pseudotime trajectories indicated that the evolutionary trajectory of T cells was from state 5 to state 1, but in the RS sample, T cells were enriched at the end of state 4, which indicated that T cells of RS sample deviated from the normal path. Richter's syndrome (RS) is an uncommon clinicopathological condition in which chronic lymphocytic leukaemia (CLL) evolves into aggressive lymphoma, the mechanism of which still remains difficult to elucidate. The IGHV 3-48*03 gene was used by both CLL cells and RS tumour cells, and establishing RS and CLL was clonally related. (H) CellphoneDB analysis showing the number of ligand-receptor interactions between (Left) B-cell clusters of CLL sample and (Right) B-cell clusters of RS sample with T-cell subgroups.
- Subjects
RICHTER syndrome; MONONUCLEAR leukocytes; KILLER cells; IMMUNOGLOBULIN light chains; REGULATORY T cells
- Publication
British Journal of Haematology, 2023, Vol 202, Issue 5, p1055
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18952