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- Title
An updated meta-analysis for association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer.
- Authors
Wen-Zhou Liu; Yu Sun; Xu Feng; Xiao-Han Bi; Tao Liu; Hua-Fu Zhou; Liu, Wen-Zhou; Sun, Yu; Feng, Xu; Bi, Xiao-Han; Liu, Tao; Zhou, Hua-Fu
- Abstract
<bold>Aim Of Study: </bold>The conclusions on the association between glutathione S-transferase P1 (GSTP1) gene polymorphism and lung cancer risk are still debated. This meta-analysis was performed to update the association between GSTP1 and the risk of lung cancer.<bold>Materials and Methods: </bold>The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method.<bold>Results: </bold>Fifty reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and lung cancer susceptibility. The association between GSTPI G allele/GG genotype and lung cancer risk was found in this meta-analysis (G allele: odds ratio [OR] = 1.08, 95% confidence interval [CI]: 1.02-1.14, P = 0.006; GG genotype: OR = 1.09, 95% CI: 1.00-1.18, P = 0.04). However, the AA genotype was not associated with the susceptibility of lung cancer.<bold>Conclusion: </bold>GSTP1 G allele/GG genotype is associated with the lung cancer susceptibility.
- Subjects
LUNG cancer; GLUTATHIONE; META-analysis; SINGLE nucleotide polymorphisms; DISEASE susceptibility; ALLELES; COMPARATIVE studies; GENETIC polymorphisms; LUNG tumors; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TRANSFERASES; EVALUATION research
- Publication
Journal of Cancer Research & Therapeutics, 2018, Vol 14, pS1084
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.199455