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- Title
Sinonasal Tumors Masquerading as Invasive Fungal Sinusitis (IFS).
- Authors
Pak, Kaitlynne Y.; Hsue, Victor B.; Lee, Matthew K.; Chen, Michelle M.; Balzer, Bonnie; Wu, Arthur W.; Tang, Dennis M.
- Abstract
Objectives: Fungal tissue invasion in the setting of sinonasal malignancy has been rarely described in the literature. Only a handful of studies have discussed cases of suspected chronic and acute IFS (CIFS and AIFS, respectively), having an underlying undifferentiated sinonasal carcinoma, sinonasal teratocarcinosarcoma, and NK/T-cell lymphoma. Methods: Here, we describe 3 cases of carcinoma mimicking IFS from a single institution. Results: Each of our patients presented with sinonasal complaints as an outpatient in the setting of immunosuppression. Intranasal biopsies consistently were predominated by necrotic debris, with and without fungal elements, ultimately leading to a delay of oncologic care. The final pathologies included NK/T-cell lymphoma and SNEC. All patients were followed by radiation and chemotherapy, with 1 case of mortality. Conclusions: We aim to emphasize the importance of obtaining viable tissue as pathology specimens as the presence of necrosis with fungal elements may limit the diagnosis and ultimately delay the care of an underlying sinonasal carcinoma.
- Subjects
PARANASAL sinus surgery; RADIOTHERAPY; PARANASAL sinus cancer; EXTRANODAL NK-T-cell lymphoma; BIOPSY; SOFT tissue infections; TRANSPLANTATION of organs, tissues, etc.; CANDIDA; EDEMA; PARANASAL sinuses; COMPUTED tomography; SKULL base; NECROSIS; IMMUNOCOMPROMISED patients; SINUSITIS; ENDOSCOPIC surgery; AMOXICILLIN; METHICILLIN-resistant staphylococcus aureus; CRANIOTOMY; TREATMENT effectiveness; CANCER chemotherapy; NUMBNESS; ADJUVANT chemotherapy; NEUROENDOCRINE tumors; CO-trimoxazole; VORICONAZOLE; SMELL disorders; DIABETES; ENDOSCOPY; MOLECULAR diagnosis; IMMUNOSUPPRESSION; CEFTRIAXONE
- Publication
Annals of Otology, Rhinology & Laryngology, 2024, Vol 133, Issue 6, p625
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/00034894241238864