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- Title
Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study.
- Authors
Rojas-Serrano, Jorge; Pérez, Leticia; García, Conrado; Moctezuma, Francisco; Álvarez-Hernández, Everardo; Vázquez-Mellado, Janitzia; Montiel, José; Burgos-Vargas, Rubén
- Abstract
The purpose of this study is to determine factors associated with a non-ACR 50 response at 6 months of follow-up, in a cohort of patients with early rheumatoid arthritis (RA). Early RA patients (symptom duration <1 year), treated with the same combination treatment (methotrexate and sulfasalazine), were included. Demographic characteristics of the patients including current smoker status (defined as a patient that smokes at least one cigarette per day), years of formal education, a 28-joint count for swelling and tenderness were registered. A basal HAQ questionnaire, visual scales for global assessment, and pain were answered by all patients, and a CDAI basal score was calculated. The ACR 50 response was determined at 6 months follow-up. Multivariable logistic regression analysis was used to calculate adjusted ORs. Two hundred twenty-five patients were evaluated, but only 144 had a complete follow-up, 43% of the latter did not reach an ACR 50 response. The only factor associated with this outcome was current smoking (OR 3.58, P < 0.008, 95% CI 1.23-11.22). Low level of formal education (≤6 years) had a tendency towards a statistical difference ( P < 0.08). After controlling with low level of formal education, sex, age in years, and CDAI baseline value with multivariable logistic regression analysis, current smoking status had an adjusted OR of 3.91 ( P < 0.009, 95% CI 1.41-10.81). Smoking is associated with a non-ACR 50 response in early rheumatoid arthritis in patients treated with a combination therapy with methotrexate and sulfasalazine.
- Subjects
RHEUMATOID arthritis; HEALTH; SMOKING; COHORT analysis; METHOTREXATE; TREATMENT effectiveness; FOLLOW-up studies (Medicine); LOGISTIC regression analysis
- Publication
Clinical Rheumatology, 2011, Vol 30, Issue 12, p1589
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-011-1775-5