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- Title
Enrichment of rare variants of BIN1 but not APOE genes in Chinese patients with Parkinson's disease.
- Authors
Li, Chun Yu; Ou, Ru Wei; Chen, Yong Ping; Gu, Xiao Jing; Wei, Qian Qian; Hou, Yan Bing; Cao, Bei; Zhang, Ling Yu; Lin, Jun Yu; Liu, Kun Cheng; Song, Wei; Zhao, Bi; Wu, Ying; Shang, Hui Fang
- Abstract
Considering that I GBA i , I TMEM175 i , and I SNCA i are risk genes for both LBD and PD, it is noteworthy to investigate whether I BIN1 i and I APOE i are also associated with the risk of PD. Keywords: APOE; BIN1; Parkinson's disease; rare variant EN APOE BIN1 Parkinson's disease rare variant 698 701 4 04/15/22 20220501 NES 220501 Abbreviations GWAS genome-wide association study LBD Lewy body dementia PD Parkinson's disease Dear Editor, Recently, Chia et al. identified five risk genes for Lewy body dementia (LBD) in a genome-wide association study (GWAS) [1]. Similarly, a previous study identified that the I BIN1 i variant rs13403026 was associated with later AAO in I GBA i -associated PD [4], suggesting the potential role of I BIN1 i in regulating AAO in PD.
- Subjects
PARKINSON'S disease; CHINESE people; LEWY body dementia; MOVEMENT disorders
- Publication
Journal of Internal Medicine, 2022, Vol 291, Issue 5, p698
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1111/joim.13444