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- Title
Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men.
- Authors
Näslund, E.; Andersson, I.; Degerblad, M.; Kogner, P.; Kral, J. G.; Rössner, S.; Hellström, P. M.
- Abstract
<bold>Objective: </bold>The aim of the present study was to identify predictors of weight loss in obese men participating in a 2-year behaviour modification programme.<bold>Design: </bold>Longitudinal, clinical intervention study of a behaviour modifying weight loss program.<bold>Setting: </bold>University Hospital, Stockholm, Sweden.<bold>Subjects: </bold>Forty-four obese men (age, 42.7 +/- 1.1 years: BMI, 37.1 +/- 0.6 kg m(-2), mean +/- SEM) followed for 2 years.<bold>Interventions: </bold>Behaviour modification weight loss programme.<bold>Main Outcome Measures: </bold>Associations between plasma leptin and thyroid function tests, insulin resistance by homeostatic model assessment (HOMA), dietary recall and anthropometrically determined body composition.<bold>Results: </bold>At baseline, there were significant correlations between plasma leptin and body mass index (BMI), fat-free mass (FFM) and insulin resistance. Median weight loss over 2 years was 4.9 kg (range, -27.2 to +11.9). Baseline serum leptin concentrations adjusted for BMI (leptin/BMI ratio) were significantly correlated with 2-year weight change (r = 0.34, P = 0.04). A subset of seven of the 44 men gained weight over the 2 years. These 'gainers' differed significantly in initial leptin/BMI ratio (0.62 +/- 0.07) compared with the 37 'losers' (0.42 +/- 0.03, P < 0.05). In a multiple regression model, baseline leptin, insulin and age predicted 22% of the variance in weight change with no additional significant contribution from BMI, FFM, waist:hip ratio, thyroid function tests or energy intake. There was a strong correlation between the change in leptin concentrations and the change in insulin resistance from baseline to 2-year follow-up (r = 0.54; P < 0.001).<bold>Conclusion: </bold>Baseline plasma leptin concentrations predicted long-term weight loss. Inappropriate leptin secretion or disposal, corrected for BMI, was associated with failure to maintain weight loss in obese men in a behaviour modification weight loss programme.
- Subjects
SWEDEN; STOCKHOLM (Sweden); WEIGHT loss; OVERWEIGHT men; LEPTIN; THYROID gland function tests; INSULIN resistance
- Publication
Journal of Internal Medicine, 2000, Vol 248, Issue 4, p299
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2000.00737.x