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- Title
The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.
- Authors
Zhang, Siyuan
- Abstract
<bold>Background: </bold>As one of the novel molecules, circRNA has been identified closely involved in the pathogenesis of many diseases. However, the function of circRNA in acute myeloid leukemia (AML) still remains unknown.<bold>Methods: </bold>In the current study, the RNA expression profiles were obtained from Gene Expression Omnibus (GEO) datasets. The differentially expressed RNAs were identified using R software and the competing endogenous RNA (ceRNA) network was constructed using Cytoscape. Functional and pathway enrichment analyses were performed to identify the candidate circRNA-mediated aberrant signaling pathways. The hub genes were identified by MCODE and CytoHubba plugins of Cytoscape, and then a subnetwork regulatory module was established.<bold>Results: </bold>A total of 27 circRNA-miRNA pairs and 208 miRNA-mRNA pairs, including 12 circRNAs, 24 miRNAs and 112 mRNAs were included in the ceRNA network. Subsequently, a subnetwork, including 4 circRNAs, 5 miRNAs and 6 mRNAs, was established based on related circRNA-miRNA-mRNA regulatory modules.<bold>Conclusions: </bold>In summary, this work analyzes the characteristics of circRNA as competing endogenous RNA in AML pathogenesis, which would provide hints for developing novel prognostic, diagnostic and therapeutic strategy for AML.
- Subjects
ACUTE myeloid leukemia; CIRCULAR RNA; RNA; JOB descriptions; GENES; RNA metabolism; ACUTE myeloid leukemia diagnosis; MOLECULAR probes; ACQUISITION of data; METABOLISM; PROGNOSIS; CELLULAR signal transduction; BIOINFORMATICS; GENE expression profiling; SURVIVAL analysis (Biometry); MOLECULAR structure; OLIGONUCLEOTIDE arrays
- Publication
BMC Cancer, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-021-08029-7