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- Title
Effects of La(III) and Ca(II) on Isolated Carassius auratus Liver Mitochondria: Heat Production and Mitochondrial Permeability Transition.
- Authors
Wu, Man; Gao, Jia-Ling; Sun, Mei-Xiang; Zhang, Ye-Zhong; Liu, Yi; Dai, Jie
- Abstract
The effects of lanthanum and calcium on heat production of mitochondria isolated from Carassius auratus liver were investigated by microcalorimetry, and their effects on mitochondrial swelling and membrane potential (Δ ψ) were determined by spectroscopic methods. La showed only inhibitory action on mitochondrial energy turnover with inhibition concentration of 50 % (IC) being 71.2 μmol L. Similarly, Ca restrained the heat production of mitochondria, and the IC of Ca was much higher than that of La. In the spectroscopic experiments, La and Ca induced fish liver mitochondrial swelling and decreased membrane potential (Δ ψ), and the induction ability of La was stronger than that of Ca. It is concluded that the effects of La and Ca on fish liver mitochondria differ, and La represents toxic action rather than Ca analogy.
- Subjects
PHYSIOLOGICAL effects of trace elements; LANTHANUM; CALCIUM; LIVER mitochondria; GOLDFISH; HEAT production (Biology); PERMEABILITY; MICROCALORIMETRY; FISHES
- Publication
Biological Trace Element Research, 2015, Vol 163, Issue 1/2, p217
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-014-0178-2