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- Title
An Environment-friendly Synthesis of 2,3-Disubstituted-2-iminothiazoline-4-ones.
- Authors
Meng, Ge; Zheng, Meilin; Dong, Mengshu; Wang, Mei; Zheng, Aqun; Guo, Zengjun
- Abstract
A series of 2,3-substituted-2-iminothiazoline-4-ones derivatives have been synthesized via an improved method including an auto-catalyzed reaction. This method avoided using any extra catalyst except for the reaction material. This method has been successful in both the aromatic substituted 2-iminothiazolines and the alkyl substituted 2-iminothiazolines. The special product with a hydroxyl group on the 2-iminogroup of 1,3-thiazoline-4-ones has also been obtained unexpectedly. The possible mechanism has been proposed for the special process of and . This method offered a special way to afford the 2-hydroxyimino-substituted thiazoline-4-one derivatives in an efficient and eco-friendly way. The mechanism of the transformation under acid condition has also been proposed.
- Subjects
THIAZOLINES; CHEMICAL synthesis; CHEMICAL reactions; HYDROXYL group; CHEMICAL derivatives
- Publication
Journal of Heterocyclic Chemistry, 2016, Vol 53, Issue 2, p588
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2323