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- Title
In Vitro Release and Degradation Study of Letrozole-Loaded Poly(Lactic-co-Glycolic Acid) Microparticles.
- Authors
Siddiqa, Akhtar Jahan; Shrivastava, Nilesh Kumar; Ali Mohsin, M. E.; Abidi, Mustufa Haider; Sharaf, Mohamed Abdel Fattah; Shaikh, Tauqeer Ahmed
- Abstract
This work describes the stability and in vitro release of letrozole (drug)-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles. To control the release capacity of the drug, the microparticles were fabricated with different ratios of biopolymer using solvent evaporation techniques. Further, the drug encapsulation efficiency, physicochemical properties, and morphologies were measured. In vitro release data of the drug were fitted to three theoretical models to evaluate the release kinetics. The highest correlation coefficient was found in Higuchi and Korsmeyer–Peppas that ensured the controlled release of the encapsulated drug from the microparticles. Scanning electron microscopy and Fourier-transform infrared spectroscopy analysis with gradual degradation time up to 80 days revealed the stability of PLGA, and stabilized the drug bioavailability.
- Subjects
CONTROLLED release drugs; DRUG bioavailability; SCANNING electron microscopy; INFRARED spectroscopy; INFRARED microscopy
- Publication
JOM: The Journal of The Minerals, Metals & Materials Society (TMS), 2021, Vol 73, Issue 1, p450
- ISSN
1047-4838
- Publication type
Article
- DOI
10.1007/s11837-020-04482-0