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- Title
Star-Shaped Block Copolymers by Copper-Catalyzed Azide-Alkyne Cycloaddition for Potential Drug Delivery Applications.
- Authors
von der Ehe, Christian; Kempe, Kristian; Bauer, Marius; Baumgaertel, Anja; Hager, Martin D.; Fischer, Dagmar; Schubert, Ulrich S.
- Abstract
Star-shaped poly(ϵ -caprolactone) is synthesized by ring-opening polymerization and subsequently functionalized with alkyne groups. These are utilized for the attachment of linear poly(ethylene glycol) monomethyl ether azide (mPEG-N3) and poly(2-ethyl-2-oxazoline) azide (PEtOx-N3) by copper-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting amphiphilic star-shaped block copolymers are characterized by SEC, MALDI-TOF mass spectrometry, NMR spectroscopy, and DLS. In order to elucidate the potential of both systems as drug carriers their loading capacity is studied with a model system, the hydrophobic dye fat brown RR. Furthermore, erythrocyte aggregation tests provide first indications that the two different star-shaped block copolymers are compatible for potential applications in a biological context.
- Publication
Macromolecular Chemistry & Physics, 2012, Vol 213, Issue 20, p2146
- ISSN
1022-1352
- Publication type
Article
- DOI
10.1002/macp.201200307