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- Title
A Glutathione-Activated Phthalocyanine-Based Photosensitizer for Photodynamic Therapy.
- Authors
He, Hui; Lo, Pui‐Chi; Ng, Dennis K. P.
- Abstract
A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer.
- Subjects
ZINC compounds; PHTHALOCYANINES; FLUORESCENCE; REACTIVE oxygen species; GLUTATHIONE; PHOTOSENSITIZERS; PHOTODYNAMIC therapy
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 21, p6241
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201400001