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- Title
Comparison of rifabutin susceptibility and rpoB mutations in multi-drug-resistant Mycobacterium tuberculosis strains by DNA sequencing and the line probe assay.
- Authors
Yoshida, Shiomi; Suzuki, Katsuhiro; Iwamoto, Tomotada; Tsuyuguchi, Kazunari; Tomita, Motohisa; Okada, Masaji; Sakatani, Mitsunori
- Abstract
We compared rifabutin susceptibility and rpoB mutations in 98 multi-drug-resistant strains of Mycobacterium tuberculosis (MDR-TB) by DNA sequencing and with a line probe assay using the commercially available INNO-LiPA Rif. TB kit (the LiPA). Our results indicated that rifabutin continues to remain active against MDR-TB strains harboring certain genetic alterations and also that the LiPA might be useful in identifying MDR-TB strains susceptible to rifabutin.
- Subjects
ANTIBIOTICS; MICROBIAL sensitivity tests; BACTERIAL genetics; GENETIC mutation; DRUG resistance in microorganisms; NUCLEOTIDE sequence; TUBERCULOSIS; BIOLOGICAL assay
- Publication
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2010, Vol 16, Issue 5, p360
- ISSN
1341-321X
- Publication type
Article
- DOI
10.1007/s10156-010-0057-5