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- Title
Absence of dentate nucleus resting-state functional connectivity changes in nonneurological patients with gadolinium-related hyperintensity on T<sub>1</sub> -weighted images.
- Authors
Mallio, Carlo A.; Piervincenzi, Claudia; Gianolio, Eliana; Cirimele, Vincenzo; Papparella, Luigi G.; Marano, Massimo; Quintiliani, Livia; Aime, Silvio; Carducci, Filippo; Parizel, Paul M.; Quattrocchi, Carlo C.
- Abstract
<bold>Background: </bold>The dentate nuclei of the cerebellum are the areas where gadolinium predominantly accumulates. It is not yet known whether gadolinium deposition affects brain functions.<bold>Purpose/hypothesis: </bold>To assess whether gadolinium-dependent high signal intensity of the cerebellum on T1 -weighted images of nonneurological adult patients with Crohn's disease is associated with modifications of resting-state functional connectivity (RSFC) of the cerebellum and dentate nucleus.<bold>Study Type: </bold>Observational, cross-sectional.<bold>Population: </bold>Fifteen patients affected by Crohn's disease were compared with 16 healthy age- and gender-matched control subjects. All participants underwent neurological, neurocognitive-psychological assessment, and blood sampling.<bold>Field Strength/sequence: </bold>1.5-T magnet blood oxygenation level-dependent (BOLD) functional MRI.<bold>Assessment: </bold>High signal intensity on T1 -weighted images, cerebellum functional connectivity, neurocognitive performance, and blood circulating gadolinium levels.<bold>Statistical Tests: </bold>An unpaired two-sample t-test (age and sex were nuisance variables) was used to investigate between-group differences in cerebellar and dentate nucleus functional connectivity. Z-statistical images were set using clusters determined by Z > 2.3 and a familywise error (FWE)-corrected cluster significance threshold of P = 0.05.<bold>Results: </bold>Dentate nuclei RSFC was not different (P = n.s.) between patients with gadolinium-dependent high signal intensity on T1 -weighted images and controls. Pre- and postcentral gyrus bilaterally and the right supplementary motor cortex showed a decrease of RSFC with the cerebellum hemispheres (P < 0.05 FWE-corrected) and was related to disease duration but not to gadodiamide cumulative doses (P = n.s.).<bold>Data Conclusion: </bold>Crohn's disease patients with gadolinium-dependent hyperintense dentate nuclei on unenhanced T1 -weighted images do not show dentate nucleus RSFC changes.<bold>Level Of Evidence: </bold>2 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:445-455.
- Subjects
DENTATE nucleus; CROHN'S disease; MOTOR cortex; FUNCTIONAL magnetic resonance imaging; DISEASE duration
- Publication
Journal of Magnetic Resonance Imaging, 2019, Vol 50, Issue 2, p445
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26669