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- Title
Early detection of myocardial involvement by T<sub>1</sub> mapping of cardiac MRI in idiopathic inflammatory myopathy.
- Authors
Yu, Liuyu; Sun, Jianhong; Sun, Jiayu; Li, Jiangbo; Dong, Yang; Zhou, Xiaoyue; Greiser, Andreas; Han, Yuchi; Zhang, Qing; Xie, Qibing; Chen, Yucheng
- Abstract
<bold>Background: </bold>Polymyositis (PM) and dermatomyositis (DM) are common types of idiopathic inflammatory myopathy (IIM), wherein patients are prone to adverse cardiovascular events.<bold>Purpose: </bold>To explore the value of cardiac magnetic resonance imaging (MRI) for detecting cardiac involvement in PM/DM patients using a T1 mapping technique.<bold>Study Type: </bold>Prospective observational study.<bold>Population: </bold>In all, 25 PM/DM patients free of cardiovascular symptoms and preserved ventricular systolic function and 25 healthy volunteers matched for age and sex served as controls.<bold>Field Strength/sequence: </bold>Cardiac MRI at 3T, including steady-state free precession (SSFP) cine imaging, late gadolinium enhancement (LGE), and T1 mapping with modified Look-Locker inversion recovery (MOLLI).<bold>Assessment: </bold>Myocardial native T1 and extracellular volume (ECV) of the left ventricle as well as the correlations with disease activity were analyzed.<bold>Statistical Tests: </bold>Independent sample's t-test, Fisher's exact test, or chi-square test, Pearson's correlation (r) were applied. P ≤ 0.05 was considered significant.<bold>Results: </bold>Left ventricular end-diastolic/end-systolic volume index (P = 0.643, P = 0.325, respectively), mass index (P = 0.719), and ejection fraction (P = 0.144) were not significantly different between PM/DM patients and controls. LGE was found in 19% of PM/DM patients and none of the control subjects. PM/DM patients showed significantly higher native T1 values (1263.7 ± 84.0 msec vs. 1200.6 ± 43.0 msec, P = 0.002) and expanded extracellular volume (ECV) (32.6 ± 3.7% vs. 26.7 ± 2.3%, P < 0.001) compared with control subjects. ECV values in PM/DM patients had a high proportion (60%) over the 95% percentile of normal controls. Meanwhile, there was a significant correlation between native T1 (r = 0.710, P = 0.0001) or ECV (r = 0.508, P = 0.01) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP).<bold>Data Conclusion: </bold>T1 mapping of cardiac MRI is valuable to detect subclinical myocardial involvement in PM/DM patients, and both myocardial native T1 and ECV could serve as early imaging markers for myocardial impairment in PM/DM.<bold>Level Of Evidence: </bold>2 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2018;48:415-422.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 48, Issue 2, p415
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25945