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- Title
General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles.
- Authors
Gribanov, Pavel S.; Philippova, Anna N.; Topchiy, Maxim A.; Minaeva, Lidiya I.; Asachenko, Andrey F.; Osipov, Sergey N.
- Abstract
An efficient access to the novel 5-(het)arylamino-1,2,3-triazole derivatives has been developed. The method is based on Buchwald–Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-Dipp)Pd(cinn)Cl] bearing expanded-ring N-heterocyclic carbene ligand is the most active catalyst for the process to afford the target molecules in high yields.
- Subjects
AROMATIC amines; ARYL halides; PALLADIUM compounds; CARBENE synthesis; CATALYSTS; HETEROCYCLIC compounds
- Publication
Molecules, 2022, Vol 27, Issue 6, p1999
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27061999