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- Title
In Vivo Anti-Inflammatory Effect, Antioxidant Activity, and Polyphenolic Content of Extracts from Capsicum chinense By-Products.
- Authors
Chel-Guerrero, Lilian Dolores; Castañeda-Corral, Gabriela; López-Castillo, Misael; Scampicchio, Matteo; Morozova, Ksenia; Oney-Montalvo, Julio Enrique; Ferrentino, Giovanna; Acevedo-Fernández, Juan José; Rodríguez-Buenfil, Ingrid Mayanín
- Abstract
By-products of Capsicum chinense Jacq., var Jaguar could be a source of bioactive compounds. Therefore, we evaluated the anti-inflammatory effect, antioxidant activity, and their relationship with the polyphenol content of extracts of habanero pepper by-products obtained from plants grown on black or red soils of Yucatán, Mexico. Moreover, the impact of the type of extraction on their activities was evaluated. The dry by-product extracts were obtained by maceration (ME), Soxhlet (SOX), and supercritical fluid extraction (SFE). Afterward, the in vivo anti-inflammatory effect (TPA-induced ear inflammation) and the in vitro antioxidant activity (ABTS) were evaluated. Finally, the polyphenolic content was quantified by Ultra-Performance Liquid Chromatography (UPLC), and its correlation with both bioactivities was analyzed. The results showed that the SFE extract of stems of plants grown on red soil yielded the highest anti-inflammatory effect (66.1 ± 3.1%), while the extracts obtained by ME and SOX had the highest antioxidant activity (2.80 ± 0.0052 mM Trolox equivalent) and polyphenol content (3280 ± 15.59 mg·100 g−1 dry basis), respectively. A negative correlation between the anti-inflammatory effect, the antioxidant activity, and the polyphenolic content was found. Overall, the present study proposed C. chinense by-products as a valuable source of compounds with anti-inflammatory effect and antioxidant activity.
- Subjects
YUCATAN (Mexico : State); MEXICO; PLANT polyphenols; SUPERCRITICAL fluid extraction; PEPPERS; RED soils; OTITIS; PLANT stems; BLACK cotton soil
- Publication
Molecules, 2022, Vol 27, Issue 4, p1323
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27041323