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- Title
Cichorins D–F: Three New Compounds from Cichorium intybus and Their Biological Effects.
- Authors
Khan, Muhammad Farooq; Nasr, Fahd A.; Noman, Omar M.; Alyhya, Nouf Abdulaziz; Ali, Iftikhar; Saoud, Mohamad; Rennert, Robert; Dube, Mthandazo; Hussain, Wahid; Green, Ivan R.; Basudan, Omer Ahmed M.; Ullah, Riaz; Anazi, Shamsa Hilal; Hussain, Hidayat; Keyzers, Rob; Gerothanassis, Ioannis P.; Choudhary, Muhammad Iqbal; Siddiqui, Hina
- Abstract
Cichorium intybus L., (chicory) is employed in various traditional medicines to treat a wide range of diseases and disorders. In the current investigation, two new naphthalane derivatives viz., cichorins D (1) and E (2), along with one new anthraquinone cichorin F (3), were isolated from Cichorium intybus. In addition, three previously reported compounds viz., β-sitosterol (4), β-sitosterol β-glucopyranoside (5), and stigmasterol (6) were also isolated from Cichorium intybus. Their structures were established via extensive spectroscopic data, including 1D (1H and 13C) and 2D NMR (COSY, HSQC and HMBC), and ESIMS. Cichorin E (2) has a weak cytotoxic effect on breast cancer cells (MDA-MB-468: IC50: 85.9 µM) and Ewing's sarcoma cells (SK-N-MC: IC50: 71.1 µM); cichorin F (3) also illustrated weak cytotoxic effects on breast cancer cells (MDA-MB-468: IC50: 41.0 µM and MDA-MB-231: IC50: 45.6 µM), and SK-N-MC cells (IC50: 71.9 µM). Moreover compounds 1–3 did not show any promising anthelmintic effects.
- Subjects
CHICORY; EWING'S sarcoma; CANCER cells; DISEASES; EMODIN; TRADITIONAL medicine; PHYTOSTEROLS
- Publication
Molecules, 2020, Vol 25, Issue 18, p4160
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25184160