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- Title
Transfer of a Multiclass Method for over 60 Antibiotics in Food from High Resolution to Low Resolution Mass Spectrometry.
- Authors
Giusepponi, Danilo; Paoletti, Fabiola; Barola, Carolina; Moretti, Simone; Saluti, Giorgio; Ianni, Federica; Sardella, Roccaldo; Galarini, Roberta; Gentili, Alessandra; Fanali, Chiara
- Abstract
A multiclass method has been developed to screen and confirm a wide range of anti-microbial residues in muscle and milk, and validated using liquid-chromatography coupled to (low-resolution, LR) tandem mass spectrometry (LC-QqQ). Over sixty antibiotics, belonging to ten distinct families, were included in the method scope. The development process was rapidly concluded as a result of two previously implemented methods. This consisted of identical sample treatments, followed by liquid chromatography, and coupled with high-resolution (HR) mass spectrometry (LC-Q-Orbitrap). The validation study was performed in the range between 10–1500 μg·kg−1 for muscles and 2–333 μg·kg−1 for milk. The main performance characteristics were estimated and, then, compared to those previously obtained with HR technique. The validity of the method transfer was ascertained also through inter-laboratory studies.
- Subjects
MASS spectrometry; ANTIBIOTICS; TANDEM mass spectrometry; LIQUID chromatography
- Publication
Molecules, 2019, Vol 24, Issue 16, p2935
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24162935