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- Title
Systematic Identification of Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro.
- Authors
Paneth, Agata; Węglińska, Lidia; Bekier, Adrian; Stefaniszyn, Edyta; Wujec, Monika; Trotsko, Nazar; Dzitko, Katarzyna
- Abstract
One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to Toxoplasma gondii. In the search for such structures, thiosemicarbazide-based compounds have emerged as a novel and promising leads. Here, a series of imidazole-thiosemicarbazides with suitable properties for CNS penetration was evaluated to determine the structural requirements needed for potent anti-Toxoplasma gondii activity. The best 4-arylthiosemicarbazides 3 and 4 showed much higher potency when compared to sulfadiazine at concentrations that are non-toxic to the host cells, indicating a high selectivity of their anti-toxoplasma activity.
- Subjects
TOXOPLASMA gondii; TOXOPLASMOSIS; CENTRAL nervous system stimulants; SULFADIAZINE; IMIDAZOLES
- Publication
Molecules, 2019, Vol 24, Issue 3, p614
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24030614