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- Title
Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.
- Authors
Tallini, Luciana R.; Osorio, Edison H.; dos Santos, Vanessa Dias; de Souza Borges, Warley; Kaiser, Marcel; Viladomat, Francesc; Zuanazzi, José Angelo S.; Bastida, Jaume
- Abstract
The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions.
- Subjects
HIPPEASTRUM; ALKALOIDS; MOLECULAR docking; CHOLINESTERASE inhibitors; EPIMERASES
- Publication
Molecules, 2017, Vol 22, Issue 12, p2191
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22122191