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- Title
Pharmacokinetic Comparison of Seven Major Bio-Active Components in Normal and Blood Stasis Rats after Oral Administration of Herb Pair Danggui-Honghua by UPLC-TQ/MS.
- Authors
Yi Jin; Yu-Ping Tang; Zhen-Hua Zhu; Er-Xin Shang; Han-Qing Pang; Xu-Qin Shi; Yan-Yan Chen; Jin Wang; Xing Chang; An Kang; Gui-Sheng Zhou; Ya-Jun Shi; Jin Sun; Zhi-Shu Tang; Shao-Ping Li; Jin-Ao Duan
- Abstract
The compatibility between Danggui (Angelicae Sinensis Radix) and Honghua (Carthami Flos) is a known herb pair, which could activate blood circulation and dissipate blood stasis effects. In this paper, we quantified seven main bio-active components (hydroxysafflor yellow A, caffeic acid, p-coumaric acid, kaempferol-3-O-rutinoside, ferulic acid, 3-n-butylphthalide, and ligustilide) in plasma samples in vivo by UPLC-TQ/MS method and investigatedwhether the pharmacokinetic (PK) behaviors of the seven components could be altered in blood stasis rats after oral administration of the Gui-Hong extracts. It was found that the Cmax and AUC0-t of these components in blood stasis rats had increasing tendency compared with normal rats. Most components in model and normal rats had significant difference in some pharmacokinetic parameters, which indicated that the metabolism enzymes and transporters involved in the metabolism and disposition of these bio-active componentsmay bealtered in blood stasis rats. This study was the first report about the pharmacokinetic investigation between normal and blood stasis rats after oral administrationof Gui-Hong extracts, and these results are important and valuable for better clinical applications of Gui-Hong herb pair and relatedTCM formulae.
- Subjects
MEDICINAL plants; USEFUL plants; BLOOD circulation; PHARMACOKINETICS; PHARMACOLOGY; DRUG metabolism
- Publication
Molecules, 2017, Vol 22, Issue 10, p1746
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22101746