We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serological evidence of Zika virus infection in non-human primates in Zambia.
- Authors
Wastika, Christida E.; Sasaki, Michihito; Yoshii, Kentaro; Anindita, Paulina D.; Hang'ombe, Bernard M.; Mweene, Aaron S.; Kobayashi, Shintaro; Kariwa, Hiroaki; Carr, Michael J.; Hall, William W.; Eshita, Yuki; Orba, Yasuko; Sawa, Hirofumi
- Abstract
Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutralization test (PRNT) to quantify neutralizing antibodies. PRNT revealed that sera from NHPs (African green monkeys and baboons) exhibited neutralizing activity against ZIKV (34.4%; 33/96), whereas a PRNT for yellow fever virus using NHP sera showed no neutralization activity. ZIKV genomic RNA was not detected in splenic tissues from NHPs, suggesting that the presence of anti-ZIKV neutralizing antibodies represented resolved infections. Our evidence suggests that ZIKV is maintained in NHP reservoirs in Zambia.
- Subjects
ZAMBIA; ZIKA virus infections; FLAVIVIRAL diseases; CERCOPITHECUS aethiops; YELLOW fever; PRIMATES
- Publication
Archives of Virology, 2019, Vol 164, Issue 8, p2165
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-019-04302-0