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- Title
Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival.
- Authors
Ignatov, Tanja; Eggemann, Holm; Burger, Elke; Ortmann, Olaf; Costa, Serban Dan; Ignatov, Atanas
- Abstract
Background: Oophorectomy is generally performed in patients with endometrial cancer despite the rate of ovarian metastasis being relatively low.Patients and methods: A multicenter retrospective registry-based study was performed in 2329 patients with endometrial cancer. The outcome measures were the incidence of ovarian metastasis and the impact on overall survival.Results: Median follow-up was performed at 84 months. A total of 2158 women were eligible for analysis, of which 131 (6.1%) had ovarian metastasis. Women with ovarian metastasis were more likely to have > 50% myometrial invasion, undifferentiated nonendometrioid tumors, and lymph and vascular space invasion. The presence of < 50% myometrial invasion, endometrioid histology, well-differentiated cancer, and negative lymph and vascular space invasion were associated with a very low rate (0.5%) of ovarian metastasis. Notably, after matching for tumor histology and grade, myometrial invasion, and lymph and vascular space invasion, ovarian metastasis was not associated with a reduced median overall survival.Conclusions: Ovarian preservation should be offered to premenopausal women with endometrial cancer in whom myometrial invasion is less than 50%, the histological type is endometrioid and well-differentiated, and lymph and vascular space invasion is not involved.
- Subjects
ENDOMETRIAL cancer risk factors; OVARIECTOMY; OVARIAN cancer; RISK of metastasis; PERIMENOPAUSE
- Publication
Journal of Cancer Research & Clinical Oncology, 2018, Vol 144, Issue 6, p1103
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-018-2628-2