We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Medical genetics: A marker for Stevens-Johnson syndrome.
- Authors
Chung, Wen-Hung; Hung, Shuen-lu; Hong, Hong-Shang; Hsih, Mo-Song; Yang, Li-Cheng; Ho, Hsin-Chun; Wu, Jer-Yuarn; Chen, Yuan-Tsong
- Abstract
Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.
- Subjects
ALLERGIES; EPIDERMIS; GENETIC disorders; PATHOLOGY; DRUGS; IMMUNE response; HLA histocompatibility antigens
- Publication
Nature, 2004, Vol 428, Issue 6982, p486
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/428486a