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- Title
Multimodal MRI of Conduction Tracts and Anatomy of the Cerebral Gray Matter in Familial Risk of Affective Disorders and Schizophrenia.
- Authors
Tomyshev, A. S.; Lebedeva, I. S.; Kananovich, P. S.; Pomytkin, A. N.; Bazhenova, D. A.; Kaleda, V. G.
- Abstract
The present study analyzed diffusion characteristics of white matter tracts and grey matter anatomy in 48 mentally healthy participants, including first-degree relatives of patients with schizophrenia (N=13) and affective spectrum disorders (N=13). The subgroup with familial risk of schizophrenia displayed abnormalities in the structural connectivity and increased cortical thickness in the superior frontal gyrus. No differences in the analyzed characteristics were revealed in the subgroup with familial risk for affective disorders. The results are discussed within the framework of the concepts of endophenotypes and processes reflecting compensatory and protective mechanisms.
- Subjects
AFFECTIVE disorders; SCHIZOPHRENIA; DIFFUSION tensor imaging; ANATOMY; PEOPLE with schizophrenia
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 169, Issue 5, p614
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-04939-x