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- Title
Renin System of the Kidney in ISIAH Rats with Inherited Stress-Induced Arterial Hypertension.
- Authors
L. Fedoseeva; G. Dymshits; A. Markel; G. Jakobson
- Abstract
The renal renin system was studied in ISIAH rats with inherited stress-induced arterial hypertension. The expression of genes for renin (Ren1) and cyclooxygenase (Cox-2) was evaluated in renal tissue of ISIAH and WAG rats (normotensive control). Basal gene expression for Ren1 and Cox-2 in ISIAH rats was much lower than in WAG rats. Water deprivation for 11 h was followed by a 4-fold increase in Cox-2 gene expression in ISIAH rats. The increase in gene expression was insignificant in WAG rats (by 30%). Renin gene expression in renal tissue of ISIAH and WAG rats remained practically unchanged after water deprivation. We conclude that a change in Cox-2 gene expression after short-term water deprivation serves as a reliable criterion for functional strain of the renal renin system in hypertensive ISIAH rats.
- Subjects
RENIN; KIDNEY physiology; LABORATORY rats; PHYSIOLOGICAL stress; HYPERTENSION; ARTERIAL diseases; GENE expression; CYCLOOXYGENASE 2
- Publication
Bulletin of Experimental Biology & Medicine, 2009, Vol 147, Issue 2, p177
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-009-0465-7