We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats.
- Authors
L. Ermolaeva; T. Dubskaya; T. Fomina; T. Vetoshkina; V. Gol’dberg
- Abstract
Abstract Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.
- Subjects
ANTINEOPLASTIC agents; BILIARY tract; MURIDAE; ABDOMEN
- Publication
Bulletin of Experimental Biology & Medicine, 2008, Vol 145, Issue 2, p263
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-008-0066-x