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- Title
Immunogenic activity of the fish tapeworm Pterobothrium heteracanthum (Trypanorhyncha: Pterobothriidae) in BALB/c mice.
- Authors
Mattos, D.P.B.G.; Verícimo, M.A.; Lopes, L.M.S.; São Clemente, S.C.
- Abstract
The aim of this study was to verify the immunogenicity of Pterobothrium heteracanthum (Cestoda: Trypanorhyncha) crude protein extract (PH-CPE) in BALB/c mice. The parasites were obtained from Micropogonias furnieri (Osteichthyes: Sciaenidae). Groups of six mice were each immunized with 10, 50 or 100 μg of PH-CPE, on days 0 and 35. Both specific IgG and IgE responses were developed after immunization. The immunoblot assay revealed that specific IgG recognizes PH-CPE proteins with two molecular weight ranges, 60–75 and 30–40 kDa, and that IgE recognizes larger proteins over 120 kDa. This appears to be the first report on the immunogenicity of metacestodes within the Pterobothriidae and that PH-CPE is a potential inducer of a specific IgE response.
- Subjects
IMMUNOGENETICS; DIPHYLLOBOTHRIUM latum; LABORATORY mice; TRYPANORHYNCHA; MICROBIAL proteins; MICROPOGONIAS furnieri; IMMUNIZATION; IMMUNOGLOBULIN G
- Publication
Journal of Helminthology, 2015, Vol 89, Issue 2, p203
- ISSN
0022-149X
- Publication type
Article
- DOI
10.1017/S0022149X13000795