We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Robotic Transrectal Computed Tomographic Ultrasound with Artificial Neural Network Analysis: First Validation and Comparison with MRI-Guided Biopsies and Radical Prostatectomy.
- Authors
Harland, Niklas; Russo, Giorgio I.; Kaufmann, Sascha; Amend, Bastian; Rausch, Steffen; Erne, Eva; Scharpf, Marcus; Nikolaou, Konstantin; Stenzl, Arnulf; Bedke, Jens; Kruck, Stephan
- Abstract
Introduction: There is still a lack of availability of high-quality multiparametric magnetic resonance imaging (mpMRI) interpreted by experienced uro-radiologists to rule out clinically significant PC (csPC). Consequently, we developed a new imaging method based on computed tomographic ultrasound (US) supported by artificial neural network analysis (ANNA). Methods: Two hundred and two consecutive patients with visible mpMRI lesions were scanned and recorded by robotic CT-US during mpMRI-TRUS biopsy. Only significant index lesions (ISUP ≥2) verified by whole-mount pathology were retrospectively analyzed. Their visibility was reevaluated by 2 blinded investigators by grayscale US and ANNA. Results: In the cohort, csPC was detected in 105 cases (52%) by mpMRI-TRUS biopsy. Whole-mount histology was available in 44 cases (36%). In this subgroup, mean PSA level was 8.6 ng/mL, mean prostate volume was 33 cm3, and mean tumor volume was 0.5 cm3. Median PI-RADS and ISUP of index lesions were 4 and 3, respectively. Index lesions were visible in grayscale US and ANNA in 25 cases (57%) and 30 cases (68%), respectively. Combining CT-US-ANNA, we detected index lesions in 35 patients (80%). Conclusions: The first results of multiparametric CT-US-ANNA imaging showed promising detection rates in patients with csPC. US imaging with ANNA has the potential to complement PC diagnosis.
- Subjects
ARTIFICIAL neural networks; RADICAL prostatectomy; ULTRASONIC imaging; MAGNETIC resonance imaging; ROBOTICS; PROSTATE cancer; RETENTION of urine
- Publication
Urologia Internationalis, 2022, Vol 106, Issue 1, p90
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000517674