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- Title
Effects of transcranial direct current stimulation on sleep disorders in Parkinson's disease: a randomized, single-blind controlled trial.
- Authors
LU Jianjun; HAN Yu; YU Qiumin; LIU Jiawen; ZHU Minghua; LIN Jinzhi; ZHANG Yang; ZHANG Yong; WANG Jinjian
- Abstract
Objective To investigate the efficacy of transcranial direct current stimulation (tDCS) on sleep disorder in patients with Parkinson's disease (PD). Methods From July 2021 to July 2023, patients with PD and sleep disorders in the Department of Neurosurgery of the Second People's Hospital of Guangdong Province were selected. The enrolled patients were divided into sham stimulation group (n = 28 ) and true stimulation group (tDCS) (n = 29) according to the inclusion and exclusion criteria. MDS-UPDRS, PDSS and other rating scales were used to evaluate the patients. Before and after tDCS treatment, MS-11 was used for intelligent sleep monitoring. The baseline and improvement of sleep disorders in the two groups before and after treatment were analyzed. Results Before tDCS treatment, there was no significant difference in general conditions and scale scores between the two groups (P > 0.05). There was no significant difference in polysomnographic monitoring results between the two groups before treatment (P > 0.05). Compared with pre-treatment, there was no significant difference in sleep monitoring results in the sham stimulation group (P > 0.05), while the sleep duration and sleep efficiency significantly increased, the nighttime awakening duration, nighttime awakening frequency, MDS-UPDRS-III score, and LEDD dose significantly decreased in the true stimulation group, with statistical significance (P < 0.05). Conclusion Pharmacological treatment combined with tDCS treatment is effective for sleep disorders and motor function in patients with PD, which could increase the sleep duration and sleep efficiency of PD patients with sleep disorders to a certain extent, reduce the nighttime awakening duration and frequency, thereby improving the fatigue symptoms during the daytime, and improving the efficacy of conventional pharmacological treatment for PD.
- Publication
Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 11, p1488
- ISSN
1006-5725
- Publication type
Article
- DOI
10.3969/j.issn.1006-5725.2024.11.004