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- Title
Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells.
- Authors
Albegova, D.; Kamkina, O.; Pavlova, S.; Albegova, Zh.; Laptev, O.; Kozlov, I.
- Abstract
An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4 T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit.
- Subjects
BIOFLAVONOIDS; MONONUCLEAR leukocytes; QUERCETIN; ENDOCRINE secretions; POLYPHENOLS
- Publication
Bulletin of Experimental Biology & Medicine, 2015, Vol 159, Issue 5, p626
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-015-3031-5