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- Title
Role of Nicotinic and Muscarinic Cholinoreceptors in the Realization of the Cholinergic Anti-Infl ammatory Pathway during the Early Phase of Sepsis.
- Authors
Zabrodskii, P.; Lim, V.; Shekhter, M.; Kuzmin, A.
- Abstract
Stimulation of nicotinic and muscarinic cholinoreceptors (nAChR, mAChR) in outbred albino mice with nicotine and aceclidine, respectively, in single equilethal doses 0.5 DL 6 h before sepsis induction signifi cantly reduced animal mortality due to a decrease in blood concentrations of proinfl ammatory cytokines IL-1β, IL-6, and MIP-2. Stimulation of mAChR (injection of aceclidine) stimulated the neutrophilic phagocytic and metabolic activity. Realization of the cholinergic anti-infl ammatory pathway (stimulation of the peripheral nicotinic cholinoreceptors (α7nAChR) and central muscarinic cholinoreceptors (mAChR) was modulated by stimulation of the muscarinic cholinoreceptors of the phagocytic monocytic system cells.
- Subjects
SEPSIS; CHOLINERGIC mechanisms; ANTI-inflammatory agents; EXPERIMENTAL pharmacology; EXPERIMENTAL toxicology
- Publication
Bulletin of Experimental Biology & Medicine, 2012, Vol 153, Issue 5, p700
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-012-1803-8