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- Title
Functional disability can deteriorate despite suppression of disease activity in patients with rheumatoid arthritis: a large observational cohort study.
- Authors
Seto, Yohei; Inoue, Eisuke; Shidara, Kumi; Hoshi, Daisuke; Sugimoto, Naoki; Sato, Eri; Tanaka, Eiichi; Nakajima, Ayako; Taniguchi, Atsuo; Momohara, Shigeki; Yamanaka, Hisashi
- Abstract
Objective: To analyze the relationship between the progression of disability and disease activity in patients with rheumatoid arthritis (RA) in daily practice. Methods: Patients from an observational cohort, IORRA, who completed surveys during 2009–2011 were eligible. Linear regression of disease activity score 28 (DAS28), Japanese version of Health Assessment Questionnaire (J-HAQ), and EQ-5D from baseline were calculated, and the angles of the regression lines were designated DAS28 slope, J-HAQ slope, and EQ-5D slope, respectively, in each patient; averages were compared between treatment groups. Results: A total of 5,038 patients [84.0 % female, mean age 59.4 (SD 13.1) years, disease duration 13.2 (9.6) years, DAS28 3.29 (1.14), and J-HAQ 0.715 (0.760)] were analyzed. The average DAS28 slope indicated improvement in all groups, whereas J-HAQ slopes were negative in patients on methotrexate (MTX), biologics, combination biologics/disease-modifying antirheumatic drugs (DMARDs), and combination biologics/MTX at baseline, but positive in patients on prednisolone >5 mg/day [0.010 (0.153)] and not on MTX at baseline [0.007 (0.122)], representing a worsening of disability. Conclusion: There is some disparity between improvement of disease activity and progression of disability, suggesting that quality of remission must be considered.
- Subjects
DISABILITIES; FUNCTIONAL analysis; RHEUMATOID arthritis; MEDICAL practice; QUESTIONNAIRES; COHORT analysis; SCIENTIFIC observation; PATIENTS
- Publication
Modern Rheumatology, 2013, Vol 23, Issue 6, p1179
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-012-0816-5