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- Title
Structural and Metabolic Features of Two Different Variants of Multiple Sclerosis: A PET/MRI Study.
- Authors
Bolcaen, Julie; Acou, Marjan; Mertens, Koen; Hallaert, Giorgio; Van den Broecke, Caroline; Achten, Eric; Goethals, Ingeborg
- Abstract
ABSTRACT BACKGROUND Multimodality imaging such as proton magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) have provided information specific to the underlying mechanisms of many brain diseases, including multiple sclerosis (MS). PURPOSE To determine the structural and metabolic characterization of two particular variants of MS, namely tumefactive MS and Balo's concentric sclerosis (BCS). METHODS Conventional MR imaging, diffusion and perfusion MR, MR spectroscopy and PET imaging with F-18 fluorodeoxyglucose (FDG) and F-18 fluoromethylcholine (FCho) were performed. RESULTS In a case with pathologically proven tumefactive MS, magnetic resonance imaging (MRI) showed a pseudotumoral lesion with incomplete ring enhancement, peripheral diffusion restriction, and high choline and lactate peaks on MRS. On follow-up, the lesion showed significant growth. In a case of BCS, MRI showed an onion-like lesion without contrast enhancement or diffusion restriction, and only a moderate increase in choline on MRS. The lesion remained stable on follow-up. On PET, there was no uptake of F-18 FDG in either type of MS lesion. Conversely, uptake of F-18 FCho was moderate in tumefactive MS, whereas no F-18 FCho uptake was noted in the lesion with, on MRI, typical features of BCS. CONCLUSIONS Our findings illustrate that metabolic features may differ between variants of MS possibly signifying different disease activity.
- Subjects
PROTON magnetic resonance spectroscopy; POSITRON emission tomography; METABOLISM; MAGNETIC resonance imaging
- Publication
Journal of Neuroimaging, 2013, Vol 23, Issue 3, p431
- ISSN
1051-2284
- Publication type
Article
- DOI
10.1111/j.1552-6569.2012.00760.x