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- Title
Orally supplemented L-arginine impairs amino acid absorption depending on dose in horses.
- Authors
Kelley, D. E.; Warren, L. K.; Mortensen, C. J.
- Abstract
The beneficial effect of L-arginine (L-Arg) supplementation, on the physiology of several species, has generated an interest in the use of L-Arg as a nutraceutical in horses, but dosage and absorption of orally supplemented L-Arg must be inferred from other species. The study objective was to determine the effect of 2 oral L-Arg doses on plasma arginine concentrations and the effect on absorption of other amino acids in mares. In Experiment 1, mares were blocked by age and breed and were fed L-Arg supplemented (supplemented with 0.025% BW L-Arg; n = 6) or control (no supplement; n = 6) concentrate on a single day with blood samples taken at 0, 0.5, 1, 2, 3,4, and 5 h relative to feeding. In Experiment 2, mares (« = 6) were used in a 3 x 3 Latin square design with L-Arg (0.0125% of BW), urea (0.0087% of BW), and control (no supplement) fed mixed into a grain concentrate as single meal with blood samples taken at 0, 1,2, 4, 6, 8,10, and 12 h relative to feeding. In Experiment 1, L-Arg supplementation increased (P < 0.05) plasma L-Arg and ornthine concentrations and decreased (P < 0.05) lysine and methionine concentrations compared with the control group. At 1 h post feeding, L-Arg mares had lower (P < 0.05) plasma concentrations of histidine, glutamic acid, proline, isoleucine, threonine, phenylalanine, leucine, valine, alanine, and taurine. In Experiment 2, L-Arg supplementation increased (P < 0.05) arginine and ornithine concentrations compared with urea and control; there was no difference among other amino acids. These experiments indicate that L-Argis absorbed and, dependent on the dose, alters the absorption of other amino acids in mares.
- Subjects
PHYSIOLOGICAL effects of arginine; AMINO acids; DIETARY supplements; HORSE feeding &; feeds; BLOOD testing
- Publication
Journal of Animal Science, 2014, Vol 92, Issue 12, p5560
- ISSN
0021-8812
- Publication type
Article
- DOI
10.2527/jas.2014-7690