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- Title
Bisphosphonates and dental implants: A meta-analysis.
- Authors
Chrcanovic, Bruno Ramos; Albrektsson, Tomas; Wennerberg, Ann
- Abstract
Objective: To test the null hypothesis of no difference in the implant failure rates, marginal bone loss, and postoperative infection for patients receiving or not receiving bisphosphonates, against the alternative hypothesis of a difference. Method and Materials: An electronic search was undertaken in October 2015 in PubMed/Medline, Web of Science, and Embase, plus hand-searching and databases of clinical trials. Eligibility criteria included clinical human studies, either randomized or not. Results: A total of 18 publications were included in the review. Concerning implant failure, the meta-analysis found a risk ratio of 1.73 (95% confidence interval [CI] 1.21-2.48, P = .003) for patients taking bisphosphonates, when compared to patients not taking the medicament. The probability of an implant failure in patients taking bisphosphonates was estimated to be 1.5% (0.015, 95% CI 0.006- 0.023, standard error [SE] 0.004, P < .001). It cannot be suggested that bisphosphonates may affect the marginal bone loss of dental implants, due to a limited number of studies reporting this outcome. Due to a lack of sufficient information, meta-analysis for the outcome "postoperative infection" was not performed. Conclusion: The results of the present study cannot suggest that the insertion of dental implants in patients taking BPs affects the implant failure rates, due to a limited number of published studies, all characterized by a low level of specificity, and most of them dealing with a limited number of cases without a proper control group. Therefore, the real effect of BPs on the osseointegration and survival of dental implants is still not well established.
- Subjects
DIPHOSPHONATES; SYSTEMATIC reviews; CONFIDENCE intervals; DENTAL implants; MEDICAL information storage &; retrieval systems; RESEARCH methodology; MEDLINE; META-analysis; ONLINE information services; PROBABILITY theory; SURGICAL complications; OSSEOINTEGRATION; EFFECT sizes (Statistics); TREATMENT effectiveness; DATA analysis software
- Publication
Quintessence International, 2016, Vol 47, Issue 4, p329
- ISSN
0033-6572
- Publication type
Article
- DOI
10.3290/j.qi.a35523