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- Title
PET imaging of PD-L1 with a small molecule radiotracer.
- Authors
Zhao, Yajie; Hsu, Jessica C.; Hu, Shuo; Cai, Weibo
- Abstract
The article discusses the use of positron emission tomography (PET) imaging for the visualization and quantification of programmed cell death protein 1 (PD-1) and its ligand PD-L1 in cancer treatment. The development of small molecule radiotracers for PET imaging of PD-L1 is explored as an alternative to radiolabeled antibodies, with advantages including rapid clearance and improved tissue penetration. Various small molecule tracers, such as WL12, PEG-TPP-1, nanobodies, and D-peptides, are discussed, highlighting their potential for PET imaging of PD-L1 expression in tumors. The article also introduces a novel small-molecule radiotracer called [68Ga]Ga-D-PMED, which shows promise for visualizing PD-L1 expression in vivo. Comparative studies of different tracers can provide insights into their strengths and limitations, aiding in the development of improved PET imaging strategies for personalized immunotherapy in cancer patients.
- Subjects
POSITRON emission tomography; SMALL molecules; PROGRAMMED death-ligand 1; RADIOACTIVE tracers; DOCETAXEL; BRAF genes
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2024, Vol 51, Issue 6, p1578
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-024-06663-4