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- Title
Reduced Incidence of Carbapenem-Resistant Klebsiella pneumoniae Infections in Cardiac Surgery Patients after Implementation of an Antimicrobial Stewardship Project.
- Authors
Giacobbe, Daniele Roberto; Salsano, Antonio; Del Puente, Filippo; Campanini, Francesco; Mariscalco, Giovanni; Marchese, Anna; Viscoli, Claudio; Santini, Francesco
- Abstract
Infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) are associated with increased mortality in cardiac surgery patients. In this short communication, we report on the changes in the incidence of CR-Kp colonization and CR-Kp infection in cardiac surgery patients from 2014 to 2018 in a teaching hospital in Italy, after the implementation of an antimicrobial stewardship project in 2014. During the study period, 2261 patients underwent open-heart surgery. Of them, 130 were found to be colonized by CR-Kp (5.7%) and 52 developed a postoperative CR-Kp infection (2.3%). The crude in-hospital mortality in patients with CR-Kp infections was 48% (25/52). The incidences of both CR-Kp colonization (incidence rate ratio (IRR) 0.82, 95% confidence intervals (CI) 0.78–0.86, p < 0.001) and CR-Kp infection (IRR 0.76, 95% CI 0.69–0.83, p < 0.001) considerably decreased over the study period. This encouraging result should prompt further concerted efforts, directed towards retaining the positive impact of stewardship and infection-control interventions on CR-Kp-related morbidity in the long term.
- Subjects
ITALY; KLEBSIELLA pneumoniae; CARDIAC surgery; CARDIAC infections; CARDIAC patients; HOSPITAL mortality; KLEBSIELLA infections; CARBAPENEMS; DRUG resistance in bacteria
- Publication
Antibiotics (2079-6382), 2019, Vol 8, Issue 3, p132
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics8030132