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- Title
Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C.
- Authors
Mitsuyoshi, Hironori; Itoh, Yoshito; Sumida, Yoshio; Minami, Masahito; Yasui, Kouichirou; Nakashima, Toshiaki; Okanoue, Takeshi
- Abstract
Aim: The mechanisms by which metabolic disorders develop in patients with chronic hepatitis C are unknown. Our study aimed to test whether oxidative stress contributes to these mechanisms. Methods: The index of homeostasis model assessment–insulin resistance (HOMA–IR) and serum and hepatic levels of thioredoxin (Trx), which are markers of oxidative stress, were evaluated in 203 biopsy-proven chronic hepatitis C patients with hepatitis C virus (HCV) genotype 1 or 2 infection. HOMA–IR and Trx levels were compared with baseline values after phlebotomy in 23 patients. Results: HOMA–IR and serum Trx levels were significantly correlated with disease stage (HOMA–IR, P < 0.00001; Trx, P < 0.0001) and independently predicted fibrosis scores (HOMA–IR, P < 0.05; Trx, P < 0.005). Steatosis (%) was significantly correlated with HOMA–IR ( P < 0.00005) and Trx ( P < 0.001) stage ( P < 0.00001). Serum Trx levels were significantly correlated with HOMA–IR ( P < 0.05), even after adjustment for body mass index ( P < 0.05). Furthermore, the mRNA levels of hepatic Trx were significantly correlated with HOMA–IR ( P < 0.05) and independently-predicted HOMA–IR ( P < 0.05). The alanine aminotransferase ( P < 0.00001), Trx ( P < 0.05), and HOMA–IR ( P < 0.05) serum levels decreased significantly after phlebotomy; these effects were similar even in non-responders to interferon. Conclusion: Oxidative stress contributed to the development of IR irrespective of obesity in patients with HCV genotype 1 or 2 infection. This study could contribute to our understanding of how metabolic disorders develop and how they should be treated in chronic hepatitis C patients.
- Subjects
OXIDATIVE stress; OXIDATION-reduction reaction; PHYSIOLOGICAL stress; INSULIN resistance; HEPATITIS C
- Publication
Hepatology Research, 2008, Vol 38, Issue 4, p348
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1111/j.1872-034X.2007.00280.x