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- Title
Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects.
- Authors
Monteiro, Fernanda R.; Roseira, Tamaris; Amaral, Jonatas B.; Paixão, Vitória; Almeida, Ewin B.; Foster, Roberta; Sperandio, Adriane; Rossi, Marcelo; Amirato, Gislene R.; Apostólico, Juliana S.; Santos, Carlos A. F.; Felismino, Eduardo S.; Leal, Fabyano B.; Thomazelli, Luciano M.; Durigon, Edison L.; Oliveira, Danielle B. L.; Vieira, Rodolfo P.; Santos, Juliana M. B.; Bachi, André L. L.
- Abstract
Background: Since aging affects the immune responses against vaccination, the present study evaluated the effects of L-glutamine (Gln) supplementation in the humoral and cellular immune responses in elderly subjects, practitioners or not, of physical exercise training. Methods: Eighty-four elderly people (aged 72.6 ± 6.1), non-practitioners (NP, n = 31), and practitioners of combined-exercise training (CET, n = 53) were submitted to Influenza virus vaccination and supplemented with Gln (0.3 g/kg of weight + 10 g of maltodextrin, groups: NP-Gln (n = 14), and CET-Gln (n = 26)), or placebo (10 g of maltodextrin, groups: NP-PL (n = 17), and CET-PL (n = 27)). Blood samples were collected pre (baseline) and 30 days post-vaccination and supplementation. Results: Comparing with the baseline values, whereas the NP-Gln and CET-PL groups showed higher specific-IgM levels, the CET-Gln group showed higher specific-IgM and IgA levels post-vaccination. The titer rate of hemagglutination inhibition was higher in the CET-Gln, NP-PL, and NP-Gln groups post-vaccination than baseline values. The absolute number of naive and effector CD4+ T cells was higher especially in the NP-Gln and CET-Gln groups, whilst activated CD4+ T cells were higher in CET subgroups post-vaccination. Conclusion: Our results showed that both l-glutamine supplementation and combined-exercise training can improve the immune responses to the Influenza virus vaccine in elderly subjects.
- Subjects
INFLUENZA vaccines; INFLUENZA A virus; FLU vaccine efficacy; OLDER people; EXERCISE; HUMORAL immunity; EXERCISE tolerance
- Publication
Vaccines, 2020, Vol 8, Issue 4, p685
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines8040685