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- Title
Ischemic optic neuropathies and their models: disease comparisons, model strengths and weaknesses.
- Authors
Bernstein, Steven; Miller, Neil
- Abstract
Ischemic optic neuropathies (IONs) describe a group of diseases that specifically target the optic nerve and result in sudden vision loss. These include nonarteritic and arteritic anterior ischemic optic neuropathy (NAION and AAION) and posterior ischemic optic neuropathy (NPION, APION). Until recently, little was known of the mechanisms involved in ION damage, due to a lack of information about the mechanisms associated with these diseases. This review discusses the new models that closely mimic these diseases (rodent NAION, primate NAION, rodent PION). These models have enabled closer dissection of the mechanisms involved with the pathophysiology of these disorders and enable identification of relevant mechanisms and potential pathways for effective therapeutic intervention. Descriptions of the different models are included, and comparisons between the models, their relative similarities with the clinical disease, as well as differences are discussed.
- Subjects
OPTIC nerve diseases; NEUROPATHY; VISION disorders; NEUROOPHTHALMOLOGY; DRUG development; DIAGNOSIS; DISEASE risk factors
- Publication
Japanese Journal of Ophthalmology, 2015, Vol 59, Issue 3, p135
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-015-0373-5