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- Title
Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in conjunctival melanomas and clinical implications.
- Authors
Kim, Hyoung Kyun; Chae, Seoung Wan; Woo, Kyung In; Kim, Yoon-Duck
- Abstract
To investigate the expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in conjunctival melanomas and their correlations with clinicopathologic parameters and prognosis. Fourteen conjunctival melanoma tissue samples and nine conjunctival nevus tissue samples were stained immunohistochemically for MMP-2, MMP-9, and TIMP-1. Association of MMP-2, MMP-9, and TIMP-1 expression in melanoma tissues with clinical progression in terms of metastasis, recurrence, mitotic index, thickness, base diameter, and invasion depth was analyzed. In the melanoma group, 78.6% of samples showed a positive reaction for MMP-2, 85.7% for MMP-9, and 100% for TIMP-1. In the nevus group, 11.1% showed a positive reaction for MMP-2, 66.7% for MMP-9, and 100% for TIMP-1. MMP-2 expression was significantly more induced in conjunctival melanoma than in benign nevi ( P = 0.002). In conjunctival melanoma, MMP-9 expression was higher in tumors >1.5 mm thick ( P = 0.026) and TIMP-1 expression was higher in recurrent cases ( P = 0.03). There was no significant correlation between the expression and metastasis during the follow-up period (mean, 5 years). MMP-2, MMP-9, and TIMP-1 were expressed in the majority of conjunctival melanomas, and MMP-2 might play a role in the development and clinical behavior of conjunctival melanoma.
- Subjects
CONJUNCTIVA tumors; MELANOMA; METALLOPROTEINASES; CANCER prognosis; CONJUNCTIVITIS
- Publication
Japanese Journal of Ophthalmology, 2010, Vol 54, Issue 3, p221
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-009-0793-1