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- Title
More Evidence Links Microglia and Neuroinflammation With Hypertension.
- Authors
Cheng, Linhai; Correia, Marcelo Lima de Gusmão
- Abstract
Studies have shown that proinflammatory cytokines (PICs) and reactive oxygen species (ROS) can induce or exacerbate hypertension (HTN) acting in the central nervous system (CNS). However, as pointed out by the authors, neuronal cells and other cells besides microglia may also participate in the development of salt-induced HTN.[2] Other stress chemokines have been localized in the PVN and correlated with HTN. It is well established that neuroinflammation is associated with HTN.[1] However, studies on neurogenic origins of HTN are still being explored aimed to dissecting the CNS pathways involved in the hypertensive responses to neuroinflammation.
- Subjects
ANGIOTENSIN II; ANGIOTENSIN-receptor blockers; NEUROINFLAMMATION; MICROGLIA; PROLIFERATING cell nuclear antigen; PERILIPIN; CHEMOKINE receptors
- Publication
American Journal of Hypertension, 2022, Vol 35, Issue 9, p787
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpac081