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- Title
Distúrbio mineral e ósseo: prevalência subestimada nos estágios iniciais da doença renal crônica.
- Authors
Nogueira Quadros, Karla Amaral; Augusto de Morais, Flávio; Coelho de Vasconcelos, Francisco Edson; Watanabe, Yoshimi José Ávila; de Morais Bessa, Allan; de Rezende e Silva, Fernanda Marcelino; Marques Guedes, João Victor; Silva Belo, Vinícius; Silva Cardoso, Clareci; Otoni, Alba
- Abstract
Introduction: mineral and bone disorder (BMD) is a serious complication of chronic kidney disease (CKD) that increases risks for death from cardiovascular causes and impairs quality of life of affected patients. Objective: to evaluate the prevalence of BMD in patients with CKD and the association between estimated Glomerular Filtration Rate (eGFR) and BMD indicators (calcium, phosphorus and PTH) in non-dialysis patients. Materials and Methods: sectional study of a two-year cohort of chronic renal adults and elderly patients on conservative treatment. BMD was identified by serum values of: PTH (> 150 pg/mL) and/or hypocalcemia (Ca < 8.8mg/dl) and/or hyperphosphatemia (P > 4.6 mg/dl). The statistical analysis used: Poisson regression; Student's T, Mann Whitney and Pearson and Spearman correlations with 5% significance level. Results: BMD prevalence was 54.6% (n=41) (95% CI: 43.45 - 65.43), more frequent in women, literate, elderly, non-drinkers, non-smokers, sedentary and white skin color. Correlations between P and PTH with GFRe were significant, inverse, moderate strength (p= <0.005 and p = 0.003; correlation coefficients = - 0.312 and - 0.379 respectively). the findings of this study highlighted gaps in the monitoring of BMD-DRC by primary care, requiring a review of clinical practices. Conclusion: robust prevalence of BMD in the early stages of CKD was identified, in addition to correlations between increased phosphorus and PTH levels and worsening kidney function.
- Subjects
MORTALITY risk factors; BONE diseases; DISEASE progression; GLOMERULAR filtration rate; CHRONIC kidney failure; STATISTICS; BONES; CONFIDENCE intervals; CHRONIC diseases; CARDIOVASCULAR diseases; MANN Whitney U Test; RENAL osteodystrophy; TREATMENT effectiveness; PARATHYROID hormone; HYPERPARATHYROIDISM; T-test (Statistics); PEARSON correlation (Statistics); DISEASE prevalence; HYPOCALCEMIA; HYPERPHOSPHATEMIA; QUALITY of life; DESCRIPTIVE statistics; MINERALS; DATA analysis; EARLY diagnosis; LONGITUDINAL method; POISSON distribution; DISEASE complications
- Publication
Revista Cuidarte, 2022, Vol 13, Issue 3, p1
- ISSN
2216-0973
- Publication type
Article
- DOI
10.15649/cuidarte.2266