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- Title
Research progress of microRNA-mediated adipogenic differentiation pathway of BMSCs.
- Authors
GUO Danqing; Zhang Shuncong; Yu Miao; Liang De; Wei Qiushi
- Abstract
In the osteoporotic patients, the ability of osteoblastic differentiation decreases in bone mesenchymal stem cells (BMSCs) but the ability of adipogenic differentiation increases, leading to the bone mass loss. This can be one of the reasons of osteoporosis occurrence. MicroRNA is a class of non-coding small RNA originating from the endogenous transcription factors and plays an important role in the regulation of adipogenetic differentiation of BMSCs and adipocyte maturation. The article reviews the literatures concerning BMSCs, microRNA, and adipogenesis. It is found that microRNA regulates the adipogenic differentiation of BMSCs by controlling the expression of related factors in Wnt, BMP, and TGF-β signal pathways and promotes the maturation of adipocytes by regulating the expression of PPAR and C/EBP. Therefore, it is important to make comprehensive research on the mechanism of microRNA regulation of adipogenesis by BMSCs.
- Publication
Chinese Journal of Osteoporosis, 2015, Vol 21, Issue 1, p107
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2015.01.023