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- Title
Mechanism of bidirection regulation of the differentiation of bone marrow stromal cells by glucocorticoids.
- Authors
HUANG Simin; WANG Junling; WEI Qiushi; LIANG Qiyao; DENG Weimin
- Abstract
Osteoporosis is a systemic metabolic disease which is characterized by a decrease in bone mass as well as a deterioration of the bone micro-architecture. It leads to increase of bone fragility and risk of the fracture. Glucocorticoids are widely used for their anti-inflammation and immune modulation effects. However, excess glucocorticoids result in osteoporosis, one of the secondary osteoporosis. Bone marrow stromal cells (BMSCs) have the potential of multi-directional differentiation, from which adipocytes and osteoblasts are originated. Within the bone marrow, the differentiation into adipocytes or osteoblasts is competitively balanced. In normal range, glucocorticoids promote the osteogenic and adipogenic differentiation. During the process, glucocorticoids may combine with many different factors to up-regulate or down-regulate osteogenic differentiation. This paper reviews the mechanism of two-way regulation of BMSCs differentiation by glucocorticoid, and the prevention and treatment of hormone4nduced osteoporosis from maximized osteogenic differentiation point of view.
- Subjects
OSTEOPOROSIS; GLUCOCORTICOIDS; MESENCHYMAL stem cells; CELL differentiation; OSTEOPOROSIS treatment; OSTEOPOROSIS prevention; PHYSIOLOGY
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 11, p1379
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2014.11.026