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- Title
Chromosomal organization of transcription: in a nutshell.
- Authors
Meyer, Sam; Reverchon, Sylvie; Nasser, William; Muskhelishvili, Georgi
- Abstract
Early studies of transcriptional regulation focused on individual gene promoters defined specific transcription factors as central agents of genetic control. However, recent genome-wide data propelled a different view by linking spatially organized gene expression patterns to chromosomal dynamics. Therefore, the major problem in contemporary molecular genetics concerned with transcriptional gene regulation is to establish a unifying model that reconciles these two views. This problem, situated at the interface of polymer physics and network theory, requires development of an integrative methodology. In this review, we discuss recent achievements in classical model organism <italic>E. coli</italic> and provide some novel insights gained from studies of a bacterial plant pathogen, <italic>D. dadantii</italic>. We consider DNA topology and the basal transcription machinery as key actors of regulation, in which activation of functionally relevant genes is coupled to and coordinated with the establishment of extended chromosomal domains of coherent transcription. We argue that the spatial organization of genome plays a fundamental role in its own regulation.
- Subjects
NUCULIDAE; PLOIDY; GENETIC transcription regulation; MOLLUSK genetics; DNA supercoiling
- Publication
Current Genetics, 2018, Vol 64, Issue 3, p555
- ISSN
0172-8083
- Publication type
Article
- DOI
10.1007/s00294-017-0785-5